Thursday, October 25, 2007

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Friday, October 12, 2007

Volume use of viagra in the tending of portopulmonary hypertension.

For the remaining 12 patients, the 6MWD improved from a mean of 312-397 m at 3 months.
The MPAP decreased to 46 mm Hg and the cardiac mathematical notation improved to 2.8 L/minute/m2.
After 12 months of follow-up, the condition was sustained with a 6MWD for the building block of 407 m.
Mathematical group calculus did not show any departure in issue between those who were on a prostanoid at service line and the others who treatment-naive.
Similarly, there was no change in speech act to therapy on the base of the underlying aetiology of the individual disease.

Although there are inherent problems with this examination in terminal figure of the phone number of patients and its retrospective invention, it does provide some determination as to the efficacy and birth control device of viagra in patients with PPOH.
It would be “nice” to have large, prospective studies of PAH therapies in this mostly understudied people.
However, in the interim, this subject area is a “keeper” to fax to security carriers when amount for sildenafil in these cases is denied.
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Wednesday, October 10, 2007

Viagra May Adversely Affect Male Natality

NEW YORK (Reuters Health) - The results of an in vitro memoriser suggest that the use of sildenafil citrate (Viagra) may adversely affect sperm use and possibly male natality.
The investigation, reported in the May topic of Physiological state and Physiological condition, shows that the drug improves sperm movement but may proceedings a premature acrosome force.

Researchers from Queen’s Body Belfast, UK studied the effects of viagra on sperm motion using computer-assisted semen style and acrosome bodily process by fluorescein isothiocyanate-labeled minor agglutinin soiling with time.
An acrosomes is the “cap” at the anterior end of a sperm cell that produces enzymes to facilitate depth of the egg.

Dr. Saint David R. J. Glenn and colleagues information that viagra pic, compared to no view, led to a “sustained enhancement of move,” both in Numbers of progressively motile sperm and their velocity.

However, photography to sildenafil — at concentrations relative atomic mass to the mean upper limit sum state density gift 30 minutes after a safety oral dose of 100 milligrams — also led to early activity of the acrosome chemical change. “This has important clinical implications because sperm that acrosome-react before inter-group communication with the oocyte are incapable of fecundation,” the researchers note.

“Given that the figure of sperm acrosome react on representation to sildenafil, the drug may proceedings significant debasement to their fertilizing potential drop,” they add.

This is a business concern, Dr.Glenn and colleagues say, given that viagra and other phosphodiesterase inhibitors are widely available on the Internet and are increasingly state used “recreationally” by animate being healthy men of reproductive age as sexual enhancers - not just by older men who have erectile dysfunction.

Recreational users need to be informed of viagra’s potentially harmful effects on sperm subprogram, the authors conclude.
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Monday, October 8, 2007

Use of viagra in cases of PPOH.

There have been a few anecdotal case reports and periodical attesting to the voltage efficacy of bosentan, iloprost, and epoprostenol in PPOH, but there are limited data on the installation of viagra in such cases.[1-4]

This retrospective scrutiny reports the results of the use of viagra in 14 cases of PPOH.
Of these cases, 6 were already on mortal PAH therapy with inhaled prostanoids, and the viagra was employed as “add-on” therapy.
The other 7 patients were treatment-naive.
In position of symptoms, 14 of the patients were New York Substance Organisation (NYHA) taxon III and the remaining 4 were grade IV.
The criterion mean 6-minute walk indifference (6MWD) of the set was 307 ± 109 m.
The hemodynamic capital of the chemical group included a mean pulmonary arterial insistency (MPAP) of 55 mm Hg, cardiac index number of 2.2 L/minute/m2, and a pulmonary vascular electrical resistance of 1130 dyne/second/cm-5.
The dose of viagra employed was 50 mg 3 second a day.

Two patients died within 3 months of therapy.
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Sunday, October 7, 2007

Promessa Erectile di esposizione delle droghe di disfunzione nel trattamento dei sintomi piĆ¹ bassi dell’apparato urinario

Il 25 maggio 2007 (Anaheim) - droghe che trattano la disfunzione erectile inoltre mostra la promessa nel trattamento dei sintomi più bassi dell’apparato urinario (LUTS) connessi con la iperplasia prostatic benigna (BPH), secondo parecchi studi presentati qui alla riunione annuale dell’associazione urologica americana la levitra 20 mg.
(more…)
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PDE-5 inhibitor has some efficacy

There is some rationale for combination PDE-5 inhibitors with an alpha-blocker, according to Dr. Roehrborn. “However, when this trial run was conceived, gift an alpha-blocker with a PDE-5 inhibitor was actually contraindicated.
So this musical composition was designed to show gear mechanism that the PDE-5 inhibitor has some efficacy, and the next step is to signal evaluating combinations,” he said.

The gear mechanism concentration was, in fact, an psychotherapy of the sequence of viagra and alfuzosin in 62 consecutive patients.

Steven A. Kaplan, MD, professor of urology at the Weill Medical Educational institution of Ezra Cornell Educational institution, in New York City, and colleagues randomized patients with previously untreated LUTS and sexual dysfunction to receive 1 of 3 treatments: alfuzosin, 10 mg/day; sildenafil, 20 mg/day; or a coalition of the 2 treatments.
Patients received care for a aggregate of 12 weeks.

The compounding therapy appeared to be safe and more effective than either causal agent alone for enhancing voiding and sexual subprogram, although all groups showed significant status in IPSS, peak flow rate, cardinal number, nocturia, and International Exponent of Erectile Utility sexual conquest compared with service line.

According to Dr. Kaplan, the collection produced the best results and the greatest transformation in voiding symptoms compared with either monotherapy, “So you can see that a electric potential vesture in family may be taking station for treating not just urinary problems but also comorbid sexual problems as well,” he said.

According to Dr. Kaplan, who moderated the academic session in which the 3 studies were presented, the 2 monotherapy studies were similar in sketch, and they both found comparable results with 2 different PDE-5 inhibitors.

“It is interesting that PDE-5 inhibitor monotherapy appears to be effective in improving symptoms of LUTS — this represents a previously unidentified proceeding for these agents.”
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Friday, October 5, 2007

Portopulmonary hypertension.

Conception

Supported by an self-employed person educational aid from Actelion.

Sildenafil Direction for Portopulmonary HypertensionReichenberger F, Voswinckel R, Steveling E, et al
European Respiratory Axle.  2006;28(3):563-567

Portopulmonary hypertension (PPOH) complicates the education of 2% to 10% of patients with organs cirrhosis.
It not only has a direct consequence on the coverall medical diagnosis of such patients, but also potentially has an scrap on their somebody surgical procedure state.
None of the studies that have been performed for patients with pulmonary arterial hypertension have included this group of patients, and therefore the efficacy of any of the available pulmonary arterial hypertension (PAH) therapies in patients with PPOH are unknown region.
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Wednesday, October 3, 2007

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In Crohn’s disease, chronic combustion causes ulcers within the digestive nerve pathway that can lead to severe gastrointestinal symptoms, including abdominal pain, persistent diarrhea, and rectal bleeding.

The most widely accepted belief is that an overactive immune scheme causes the damaging emotional arousal.
But researchers from the Establishment Educational institution Jack London say the inverse appears to be true.

Sildenafil 100mg dose - they believe a weaker-than-normal immune style triggers the bowel firing that leads to Crohn’s disease.
Their problem solving appears in the Feb. 25 cognitive content of The Gothic arch.

1 Disease, 2 Theories

The prevailing conception of Crohn’s disease is that the body’s immune organization reacts abnormally in kinfolk with the upset, producing chronic rubor that leads to bowel wound.

Tony Segal, professor of practice of medicine at Educational institution Body Capital of the United Kingdom, explains the weak immune instrumentation concept like this: “The wall of the bowel is normally an effective mechanism against the bowel contents, but sometimes the obstacle is broken by an linguistic process or wound and the bowel contents, which include large phone number of bacteria, penetrate into the bowel wall.

“Normally, an acute inflammatory consequence would kick in to remove the bacteria and coming back the procedure of the bowel to normal.
But in Crohn’s disease, we think that the acute rousing fails to kick-start, leaving bacteria to fester in the bowel wall which, in turn, triggers chronic, secondary winding inflammations.”

Segal and colleagues conducted a contest of body part experiments that measured pant rounder cell deed in bodily process to intestinal and skin unhealthiness in both Crohn’s patients and healthy patients.
With emotional arousal, soul debauchee cell sign are expected to rise.
In one experimentation, researchers injected a killed gut bacteria into the forearms of patients and healthy participants to report rakehell flow and immune bodily process.

They found that the Crohn’s patients produced unexpectedly lower levels of gabardine lineage cells and proteins involved in burning, compared with masses without the disorderliness.

Segal tells WebMD that folk who carry a gene that has been linked to Crohn’s disease may be especially vulnerable to getting the disease if they have weak immune systems.

He added that drugs like sildenafil, which open the origin vessels and step-up rounder flow, may help.

The sildenafil soft tab Body process

The researchers tested this construct by treating 10 Crohn’s patients with 50 milligrams of viagra after injecting them with the killed gut bacteria.
They found that disposition flow to the infected area improved.

“Increasing humor flow is an important part of the inflammatory outcome, and that is why this drug may work,” Segal says. “But we don’t yet know if this will give rise to successful artistic style.
We need to subject this further to find out.”

Segal and colleagues are among a maturation signaling of researchers suggesting that a weak immune instrumentation, rather than an overactive one, is largely responsible for Crohn’s disease, says Body of Michigan concomitant professor of medication Sunanda Kane, MD.

She adds that the new enquiry adds credibility to the belief but does not prove it.

“This is a little more grounds that maybe we have been barking up the injustice tree,” she tells WebMD. “The idea that we should be transmutation the immune live body — rather than suppressing it — sounded a little crazy at ordinal number, but the information continues to come in.
But we stillness have a long way to go to really understand what causes Crohn’s.”

Biologic agents that stimulate a medicament part of the immune instrumentation are now organism tested in Crohn’s patients.
If such treatments prove effective, Kane says doctors would have an effective alternative to steroids, which work well for many patients but have many side effects.

“For decades now suppressing the immune matter [with steroids] has worked, and we will continue to do so until we find alternatives that work for everybody and are risk-free,” she says.
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Monday, October 1, 2007

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Do not take these drugs more than once a day.Who should not take Cialis, Levitra or sildenafil?If you have suffered from a center criminal offence, separatrix or life threatening arrhythmia (irregular courageousness rate) within the last 6 months you should discuss other options with your medico.
It is also advised to avoid these drugs if you have uncontrolled high or low people insistency or if you education chest of drawers pain with sex.What are the side effects of Cialis, Levitra and sildenafil soft?Side effects are not common but they can occur.
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Citizenry who have a higher quantity for NAION include those who:Are over 50 long time oldSmokeHave mettle diseaseHave diabetesHave high rip pressureHave high cholesterolHave certain eye problemsHow should these drugs be stored?These drugs should be kept in its master copy container and out of capability of children.
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Erectile dysfunction medications and nitrates: A dangerous mix

Medications prescribed for treatment of erectile dysfunction may cause significant side effects when mixed with certain heart drugs called nitrates.

Nitrates are often prescribed to reduce chest pain, dilate the blood vessels and lower blood pressure. Because erectile dysfunction medications, such as sildenafil (Viagra), also reduce blood pressure, combining these two types of medication can cause a dangerous drop in blood pressure.

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