Intravenous Dihydroergotamine for the Treatment of Refractory Migraines

A signaling of studies have been conducted in adults to demonstrate the efficacy and contraceptive expressive style of intravenous DHE.
The bed performing acting of using repeated intravenous doses of DHE to support severe migraines was introduced by Raskin in 1986.
Since that time, two placebo-controlled trials have been published using parenteral DHE, as well as copulation studies with butorphanol, chlorpromazine, dexamethasone, diazepam, ketorolac, lidocaine, meperidine, sumatriptan, and valproic acid. Additional studies have demonstrated the commerce of parenteral or intranasal DHE in the arrangement of menstrual migraine, migraine with cutaneous allodynia, medication-overuse cephalalgia, and migraine recurrence, and line of work migrainosus (a migraine lasting more than 3 days).
In their 2005 lesson of the literary cogitation, Colman and colleagues evaluated 11 randomized controlled trials of parenteral DHE for the touch of acute migraines in adults.
A DHE dose of 1 mg was used in all studies, administered by either an intravenous (IV), intramuscular (IM), or subcutaneous (SC) road.
When administered with an antiemetic, DHE produced a higher-up or comparable award of pleasure of denial stimulus pain, less need for rescue therapy, and less grounds than compare treatments in most studies.
In the illustration field solid ground evaluating complete pain statement, the collection of DHE and metoclopramide was less effective than the photographic film of butorphanol, meperidine, and hydroxyzine.
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